Boston saw its best-known stocks fall 0.4% while the market enjoyed a good day. When the market closed on Wednesday, the Dow Jones Industrial Average finished up 0.1%, the NASDAQ up 0.2%, and the S&P 500 up 0.1%.

Biggest Gainer
In Boston, Anika Therapeutics, Inc. (NASDAQ:ANIK) closed at $15.76 (+2.8%), making it Wednesday's biggest gainer. Coming in just behind was Staples (NASDAQ:SPLS), gaining 1.8% to close at $12.15 on volume of 14.7 million. Changing hands at 1.3 times its three-month average, the stock traded on volume of 88,301.

Biggest Loser
Wednesday's top loser was Idenix Pharmaceuticals, Inc. (NASDAQ:IDIX), closing at $5.11 (-9.4%). Lojack Corporation (NASDAQ:LOJN), another big loser, closed at $2.30 (-3.8%) on volume of 67,385. Changing hands at 4.8 times its three-month average, the stock traded on volume of 6.1 million.

Other Notable Boston Stocks
• Akamai Technologies, Inc. (AKAM): $38.96 (+31 cents)
• American Superconductor Corporation (AMSC): $3.93 (+6 cents)
• American Tower (AMT): $70.66 (-45 cents)
• Anika Therapeutics, Inc. (ANIK): $15.76 (+43 cents)
• ArQule, Inc. (ARQL): $5.39 (-7 cents)
• Biogen Idec (BIIB): $155.04 (-76 cents)
• Boston Scientific (BSX): $5.76 (+one cent)
• Boston Properties (BXP): $113.66 (-$1.29)
• Cognex Corporation (CGNX): $37.54 (-30 cents)
• Casual Male Retail Group, Inc. (CMRG): $4.50 (+2 cents)
• Charles River Laboratories (CRL): $37.96 (-32 cents)
• Constant Contact, Inc. (CTCT): $19.98 (+8 cents)
• EMC (EMC): $27.73 (+6 cents)
• Forrester Research, Inc. (FORR): $29.28 (-24 cents)
• Idenix Pharmaceuticals, Inc. (IDIX): $5.11 (-53 cents)
• Iron Mountain Incorporated (IRM): $33.65 (+38 cents)
• LoJack Corporation (LOJN): $2.30 (-9 cents)
• Pegasystems Inc. (PEGA): $29.82 (+41 cents)
• Raytheon (RTN): $58.15 (+28 cents)
• Sapient Corporation (SAPE): $10.41 (0 cents)
• Sonus Networks, Inc. (SONS): $2.12 (+one cent)
• Staples (SPLS): $12.15 (+21 cents)
• State Street (STT): $43.45 (-24 cents)
• Teradyne, Inc. (TER): $14.98 (-17 cents)
• TechTarget Inc (TTGT): $5.53 (-3 cents)
• VistaPrint Limited (VPRT): $37.53 (-20 cents)